Purification of polysaccharides from Cordyceps militaris and their anti-hypoxic effect

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Purification of polysaccharides from Cordyceps militaris and their anti‑hypoxic effect.

Acute mountain sickness, one of the most common altitude diseases, causes lung and brain injury. The present study aimed to investigate the anti‑hypoxic effect of purified polysaccharides extracted from Cordyceps militaris. The aqueous extract of Cordyceps militaris was purified progressively through a DEAE‑52 cellulose anion exchange column and a Sepharose G‑100 column. The fraction CMN1, with...

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Characterization of Alkali Extracting Polysaccharides from Cultured Cordyceps militaris

Polysaccharides from many sources, catching more and more attention because of their multiple pharmacological activities [1-4], can be extracted by hot water, alkali, and enzyme and so on. In traditional viewpoint, polysaccharides are soluble in water for their hydroxyl and the solubility is the base of its bioactivities while insoluble polysaccharides have low or no bioactivities. The predomin...

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Salinity-Induced Anti-Angiogenesis Activities and Structural Changes of the Polysaccharides from Cultured Cordyceps Militaris

Cordyceps is a rare and exotic mushroom that grows out of the head of a mummified caterpillar. Many companies are cultivating Cordyceps to meet the increased demand for its medicinal applications. However, the structures and functions of polysaccharides, one of the pharmaceutical active ingredients in Cordyceps, are difficult to reproduce in vitro. We hypothesized that mimicking the salty envir...

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Protective effects on mitochondria and anti-aging activity of polysaccharides from cultivated fruiting bodies of Cordyceps militaris.

Cordyceps militaris (L.) Link is an entomopathogenic fungus parasitic to Lepidoptera larvae, and is widely used as a folk tonic or invigorant for longevity in China. Although C. militaris has been used in traditional Chinese medicine for millennia, there is still a lack convincing evidence for its anti-aging activities. This study was performed to investigate the effects of polysaccharides from...

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Medicinal mushrooms, including Cordyceps militaris, have received attention in Korea because of their biological activities. In the fruiting body and in corpus of C. militaris, the total free amino acid content was 69.32 mg/g and 14.03 mg/g, respectively. In the fruiting body, the most abundant amino acids were lysine, glutamic acid, proline and threonine. The fruiting body was rich in unsatura...

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ژورنال

عنوان ژورنال: Molecular Medicine Reports

سال: 2014

ISSN: 1791-2997,1791-3004

DOI: 10.3892/mmr.2014.2786